The molecular mechanism that regulates TMEM63B lipid scrambling

TMEM63B, a mechanosensitive lipid scramblase, has an autoinhibitory domain in its C-terminal tail that helps keep it inactive under resting conditions, researchers from the Institute of Science Tokyo report. Changes to this regulatory region, particularly the Leu776 residue, reverse the inhibitory action and cause continuous lipid scrambling, disrupting normal phospholipid asymmetry.