Science
Transparent minispheres reveal that some look-alike cancer drugs part ways in 3D
Researchers at Uppsala University have adapted Cell Painting, a widely used imaging method in drug discovery, to look at individual cells inside small 3D clusters of cancer cells. Two drugs that looked almost identical in ordinary flat cell cultures behaved differently in 3D, and the team linked the
Researchers at Uppsala University have adapted Cell Painting, a widely used imaging method in drug discovery, to look at individual cells inside small 3D clusters of cancer cells. Two drugs that looked almost identical in ordinary flat cell cultures behaved differently in 3D, and the team linked the difference to how each drug switches on the cell's p53 stress response.
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